https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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But how can morality, the dignity from the individual, my practical experience on the which means of life, abide by through the motion of atoms? A purely naturalistic viewpoint fails here; a Christian point of view, I think, is a way more sensible way to interpret these areas of actuality.’
Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
Given that 2000, Dekker has shifted the leading target of his function in direction of biophysics where by he research the Homes of one biomolecules and cells utilizing the equipment of nanotechnology. This modification of industry was driven by his fascination to the amazing performing of Organic molecular structures, in addition to with the very long-term perspective that lots of attention-grabbing discoveries can be expected On this discipline.[5] Recent traces of exploration in his biophysics team are from the parts of:[six]
This yielded a breakthrough. Within just a few months, we were in the position to measure transportation through someone single-walled carbon nanotube. Based upon very low-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Technological know-how using an Lively analysis lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were authentic quantum wires with very prolonged (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
What distinguishes biology from chemistry is that these parts together make up a residing method. The key of stated lifetime, I believe, lies during the interactions, the interplay of All those molecules. The big problem regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from easy molecules in the extremely intricate units we see right now? We do not know. I need to work on these kinds of major, open queries.’
2011, initially in vitro measurements of transportation across just one biomimetic nuclear pore complicated; development of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination
2003, shown the initial biosensors produced out of a carbon nanotube; fixed the framework and mechanism of DNA restore proteins; and discovery of a new system for fabricating stable-condition nanopores for DNA translocation
Extremely amazing, but that wasn’t definitely in which my fascination lay. I wanted to pioneer and I had the sensation that was not doable, as the most fascinating basic insights experienced now been uncovered. But my area had formulated many thrilling new equipment to evaluate unique molecules. I decided that I wished to implement this to biology, to take a look at it from the Actual physical standpoint.’
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
Numerous new phenomena were being learned, and he and his analysis team proven a leading placement Within this subject of analysis. Dekker and his research group found out new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the primary to build a transistor based upon just one nanotube molecule.
2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-selection conformational changes in Mre11/DNA mend complexes; and first power measurements with a DNA molecule inside a nanopore
Good-state ceesdekker nanopores have proven to become a remarkably flexible probe for single-molecule analysis of DNA. I'll explain several of our new conclusions – exclusively DNA knots – and also our initiatives to increase the capabilities of strong-state nanopores even further more, during the course of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.